PEPSIN AND ITS PREPARATIONS.
نویسندگان
چکیده
منابع مشابه
Crystal structure of human pepsin and its complex with pepstatin.
The three-dimensional crystal structure of human pepsin and that of its complex with pepstatin have been solved by X-ray crystallographic methods. The native pepsin structure has been refined with data collected to 2.2 A resolution to an R-factor of 19.7%. The pepsin:pepstatin structure has been refined with data to 2.0 A resolution to an R-factor of 18.5%. The hydrogen bonding interactions and...
متن کاملThe Purification of Pepsin, Its Properties, and Physical Characters
Since 1836, when Theodor Schwann signalized the presence in gastric juice of the proteolytic ferment which he was the first to designate as pepsin, a large number of attempts have been made to isolate it in a pure form to determine its chemical nature and its ultimate physiological properties. In a large majority of these, and, especially, all those made before 1895, except that of Brticke (I),...
متن کاملThe Presence of a Gelatin-liquefying Enzyme in Crude Pepsin Preparations
A protein fraction has been isolated from crude pepsin preparations which is about 400 times as active as crystalline pepsin in the lique-faction of gelatin. The activity as measured by the digestion of casein, edestin or egg albumin is less than that of crystalline pepsin. It is more resistant to alkali than the crystalline pepsin.
متن کاملThe Autodestruction of Pepsin in Relation to Its Ionization. By
The irreversible disappearance of the activity of pepsin in alkaline solution was first recorded by Kfihne (1). I t was confirmed by Langley (2), who observed also " tha t the destruction by sodium carbonate solutions goes on very much more slowly at 15°C. than at body temperature." Langley's experiments were carried out with neutralized filtrates of extracts of rabbit gastric mucosa made with ...
متن کاملThe Autodestruction of Pepsin in Relation to Its Ionization
1. Evidence is presented that pepsin is a univalent acid with a value for pK of 6.85 (or a base, with pK 7.39). 2. The autodestruction of the pepsin is shown to be dependent in part upon an instantaneous irreversible change occurring in the ionized form of the enzyme (if it be an acid) or in the unionized form (if it be a base). 3. A further progressive autodestruction of pepsin at any given hy...
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ژورنال
عنوان ژورنال: Journal of the American Medical Association
سال: 1885
ISSN: 0002-9955
DOI: 10.1001/jama.1885.02390900002001a